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Search Results for " antifungal protein "

Targets Recommended: Antifungal

10

抑制剂 & 化合物

5

天然产物

1

化合物库

5

重组蛋白

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Cat. No.	Product Name
L9610	环肽库		55 compounds
	55 种环肽分子，可用于高通量和高内涵筛选；

化合物库

Cat.No: L9610

Compounds: 55

Cat. No.	Product Name	Target	Signaling Pathways
T4040	AN2718	Antifungal	Microbiology/Virology
	AN2718 通过 OBORT 机制抑制蛋白质合成，有抗真菌功效。
T24227	Juncin E (-)-Juncin E
	Juncin E is an 18.9 kDa antifungal protein.
T74976	Antifungal agent 46	Ras	GPCR/G Protein; MAPK
	Antifungalagent 46 (compound 2f)是一种通过抑制farnesyltransferase从而抑制Ras信号的有效抗真菌剂。
T13095	Tautomycin	Others	Others
	Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus.
T38053	Aureothin
	Aureothin is a natural nitroaryl-substituted polyketide that exhibits antitumor, antifungal, and insecticidal activities. It is a non-competitive inhibitor of NADH:ubiquinone oxidoreductase of bovine heart, N. crassa, and E. coli (IC50s = 0.07, 0.08, and 22 nmol/mg protein, respectively).
T79269	TMV-IN-5
	TMV-IN-5（化合物1a）是一种具有抗植物病毒/真菌活性的化合物。该物质能够通过与烟草花叶病毒（TMV）的CP结合，有效抑制病毒组装，有潜力用于农药开发。
T75501	Morin 3-O-β-D-glucopyranoside
	Morin 3-O-β-D-glucopyranoside 是一种天然类黄酮，具有抗真菌、抗癌和抗氧化活性。Morin 3-O-β-D-glucopyranoside 抑制逆转录酶、蛋白酪氨酸激酶和黄嘌呤氧化酶，还具有抗 HIV、抗动脉硬化和超氧化物清除活性。
T79928	Phosphomannose isomerase
	Phosphomannose isomerase 是 GDP-Man 生物合成途径中关键的首要酶，负责催化 Fru6P 与 Man6P 之间的互转。该酶对于细胞壁合成及蛋白质糖基化过程至关重要。同时，作为一种潜在的抗真菌靶点，Phosphomannose isomerase 可以有效抑制 A. flavus。
T36650	Ansatrienin B
	Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul...
T79738	CYP51/PD-L1-IN-1
	CYP51/PD-L1-IN-1（compound L11）是一种具有抗真菌活性的喹唑啉化合物，作为CYP51（IC50: 0.884 μM）和PD-L1（IC50: 0.083 μM）的双重抑制剂，能够在细胞周期早期引发真菌细胞的凋亡。该化合物还能有效减少IL-2、NLRP3、NF-κBp65等蛋白的细胞内水平，诱导线粒体损伤及ROS积聚，进而导致真菌细胞的破裂和死亡。

化合物

Cat.No: T4040

Target: Antifungal

Cat.No: T24227

Synonym: (-)-Juncin E

Antifungal agent 46

Cat.No: T74976

Target: Ras

Cat.No: T13095

Target: Others

Cat.No: T38053

Cat.No: T79269

Morin 3-O-β-D-glucopyranoside

Cat.No: T75501

Phosphomannose isomerase

Cat.No: T79928

Cat.No: T36650

CYP51/PD-L1-IN-1

Cat.No: T79738

Cat. No.	Product Name	Target	Signaling Pathways
TN2158	Robinetin 3,3',4',5',7-Pentahydroxyflavone,洋槐黄素	Anti-infection; HIV Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Robinetin (3,3',4',5',7-Pentahydroxyflavone) 是一种天然黄酮，具有显著的“两种颜色”固有荧光特性。它具有抗真菌、抗病毒、抗菌、抗突变、抗氧化和抗自由基活性，高效抑制 EYPC 膜脂质过氧化和 HbA 糖基化。
T14854	Caerulomycin A 浅蓝霉素,Cerulomycin,Caerulomycin	Antifungal	Microbiology/Virology
	Caerulomycin A (Caerulomycin) 是抗真菌和抗细菌化合物，能够诱导 T 细胞的产生。它能够抑制 IFN-γ 诱导的 STAT1 通路，从而增强 TGF-β-Smad3 信号通路。它可用于自身免疫病的研究。
T7004	Tubercidin 结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine	Influenza Virus; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Tubercidin (Sparsomycin A) 是从Streptomyces tubercidicus 得到的抗生素，抑制粪链球菌生长的IC50值为 0.02 μM。它是腺苷磷酸化酶的弱抑制剂，并干扰腺苷和 AMP 的磷酸化。它有抗病毒作用。
T1011	Itraconazole 伊曲康唑,R51211	P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells
	Itraconazole (R51211) 是三唑类抗真菌药，也是口服活性的Hedgehog 信号通路拮抗剂，IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶，从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。
TN1448	(-)-Bornyl acetate L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯	p38 MAPK; NF-κB; JNK; Antifungal	MAPK; Microbiology/Virology; NF-κB
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) 是存在于牛膝草油中的一种具有抗真菌活性的 (+)-Bornyl acetate 低活性异构体。

天然产物

Cat.No: TN2158

Synonym: 3,3',4',5',7-Pentahydroxyflavone,洋槐黄素

Target: Anti-infection, HIV Protease, Antibacterial

Cat.No: T14854

Synonym: 浅蓝霉素,Cerulomycin,Caerulomycin

Target: Antifungal

Cat.No: T7004

Synonym: 结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine

Target: Influenza Virus, DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T1011

Synonym: 伊曲康唑,R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

(-)-Bornyl acetate

Cat.No: TN1448

Synonym: L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯

Target: p38 MAPK, NF-κB, JNK, Antifungal

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00121	Antifungal Protein, Aspergillus giganteus, Recombinant (B2M & His) afp,Antifungal protein	Aspergillus giganteus	E. coli
	This protein inhibits the growth of a variety of fungal species. Antifungal Protein, Aspergillus giganteus, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 19.8 kDa and the accession number is P17737.
TMPH-03231	AFP2 Protein, Raphanus sativus, Recombinant (His & SUMO) Cysteine-rich antifungal protein 2,Defensi...	Raphanus sativus	E. coli
	Possesses antifungal activity sensitive to inorganic cations. Induces potential changes in fungal membranes and increased K(+) efflux and Ca(2+) uptake. AFP2 Protein, Raphanus sativus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 21.7 kDa and the accession number is P30230.
TMPH-02468	Mo-CBP3 Protein, Moringa oleifera, Recombinant (GST)	Moringa oleifera	E. coli
	Chitin-binding protein. Has antifungal activity against F.solani, F.oxysporum, C.musae and C.gloesporoides but not against P.oligandrum. Depending on concentration the antifungal activity can be fungistatic or fungicidal. Inhibits both spore germination and mycelial growth in F.solani at a concentration of 0.1 mg/ml. Has antifungal activity against C.krusei, C.albicans, C.tropicalis and C.parapsilosis. Has no chitinase, beta-glucanase or hemagglutinating activity. Acts as a flocculent. Mo-CBP3 P...
TMPH-00027	Aculeacin-A acylase Protein, Actinoplanes utahensis, Recombinant (His & SUMO) Aculeacin-A acylase	Actinoplanes utahensis	E. coli
	Catalyzes the hydrolysis of the palmitoyl moiety of the antifungal antibiotic, aculeacin-A, giving a hexapeptide moiety and a long chain fatty acid. Aculeacin-A acylase Protein, Actinoplanes utahensis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.1 kDa and the accession number is P29958.
TMPH-00064	MRJP1 Protein, Apis mellifera, Recombinant (His)	Apis mellifera	P. pastoris (Yeast)
	Induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kinase and inducing the 20-hydroxyecdysone protein (20E). Most abundant protein found in the royal jelly which is the food of the queen honey bee larva. The ...

重组蛋白

Antifungal Protein, Aspergillus giganteus, Recombinant (B2M & His)

Cat.No: TMPH-00121

Species: Aspergillus giganteus

Expression System: E. coli

AFP2 Protein, Raphanus sativus, Recombinant (His & SUMO)

Cat.No: TMPH-03231

Species: Raphanus sativus

Expression System: E. coli

Mo-CBP3 Protein, Moringa oleifera, Recombinant (GST)

Cat.No: TMPH-02468

Species: Moringa oleifera

Expression System: E. coli

Aculeacin-A acylase Protein, Actinoplanes utahensis, Recombinant (His & SUMO)

Cat.No: TMPH-00027

Species: Actinoplanes utahensis

Expression System: E. coli

MRJP1 Protein, Apis mellifera, Recombinant (His)

Cat.No: TMPH-00064

Species: Apis mellifera

Expression System: P. pastoris (Yeast)

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